Reconstruction of the Carotid Bifurcation in Patients With Arterial Hypertension of 2-3 Degrees

Samara State Medical University

Status: Active, not recruiting

Conditions: Symptomatic Carotid Artery Stenosis; Hypertension; Carotid Stenosis

Treatments: Procedure: Carotid endarterectomy; Procedure: Carotid stenting

Study type: Interventional

Funder types: Other

Identifiers

NCT05931003

Hypertension_after_CEA_or_CAS

Details and patient eligibility

About

Carotid endarterectomy (CEA) is a well-established procedure for preventing ischemic brain damage. Stenosis of the precerebral vessels are often combined with arterial hypertension. In recent decades, many works have appeared that indicate that the course of arterial hypertension (AH) changes after CEA. However, it remains unknown how this is related to the choice of surgical tactics.

Full description

Purpose of the study: to substantiate the choice of the method of surgical treatment in patients with a combination of hemodynamically significant stenosis of the carotid bifurcation and arterial hypertension of 2-3 degrees.

Tasks:

1. To study the course of hypertension after carotid endarterectomy with removal of the carotid glomus.
2. To study the course of hypertension in patients after stenting of the internal carotid artery.
3. To substantiate the strategy for performing carotid endarterectomy in patients with bilateral significant lesions of the internal carotid artery.
4. To substantiate the choice of a surgical treatment strategy in patients with significant stenosis of the carotid bifurcation and 2-3 degree of hypertension.

Methods for examining patients: collection of complaints and anamnesis, objective examination, questioning of patients, instrumental examination (ultrasound of BCS, daily monitoring of blood pressure, CT of the brain, cerebral angiography).

As a result of the study, the optimal tactics of surgical treatment in patients with carotid artery stenosis and the presence of hypertension will be determined.

Enrollment: 90 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Presence of symptomatic ICA stenosis 70-90%
• Arterial hypertension of 2 or 3 degrees
• CEA operation with carotid glomus removal or ICA stenting operation

Exclusion criteria

• severe diabetes
• traumatic brain injury in history
• IHD, stable angina pectoris 3-4 FC.
• presence of clinical signs of vertebrobasilar insufficiency
• the presence of significant stenosis of the renal arteries
• CKD stages 3b-5

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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90 participants in 2 patient groups

Carotid artery stenting

Experimental group

Description:

Carotid artery stenting

Treatment:

Procedure: Carotid stenting

Carotid endarterectomy

Active Comparator group

Description:

Carotid endarterectomy

Treatment:

Procedure: Carotid endarterectomy