Reconstructive Management of Peri-implantitis

Center of Implantology, Oral and Maxillofacial Surgery, Badajoz, Spain

Status: Completed

Conditions: Resolution of Pathologic Process

Treatments: Procedure: Reconstructive therapy of peri-implantitis by means of bone graft (and barrier membrane in the test group)

Study type: Interventional

Funder types: Other

Identifiers

NCT05282667

1

Details and patient eligibility

About

With the growing burden of peri-implantitis around the globe, interest has flourished on the management of this pathology. Nevertheless, lack of consensus exists in the pursuit of a predictable therapy. Different therapeutic modalities have been advocated. Non-surgical therapy as a sole modality is often insufficient to resolve inflammation. Surgical interventions have demonstrated more favorable outcomes. Amongst these, evidence supported the application of resective, reconstructive, or combined approaches to limit progressive bone loss and achieve soft tissue health. Nevertheless, up to date, the most suitable modality remains unknown and the decision-making process derives from the understanding acquired from the management of periodontitis.

One critical element regarded to successfully resolve peri-implantitis is to efficiently detoxify the contaminated implant surface. Mechanical, pharmacological and chemical strategies have been proposed to eliminate bacterial plaque and remnants from the implant surface. However, evidence has not demonstrated superiority of a given detoxification agent/strategy.

In this sense, the significance of barrier membranes is not yet well understood. Roos-Jansaker in 2014 showed that the additional use of barrier membranes did not improve the outcome. Nevertheless, since then this subject has not been a matter of research.

Full description

The effect of barrier membrane in the reconstructive management of peri-implantitis will be tested at 12-month follow-up

Enrollment: 38 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Non-smokers
• No use of antibiotics recently
• No metabolic disorder
• Infra-osseous or combined peri-implantitis defect

Exclusion criteria

• Smokers
• Pregnant
• Metabolic disorders that affect bone healing
• Supra-crestal defects

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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38 participants in 2 patient groups

Resorbable cross-linked barrier membrane

Experimental group

Description:

Bone graft will be covered with a resorbable barrier membrane to exclude undesired cells from the area aimed at being regenerated (peri-implantitis bone defect)

Treatment:

Procedure: Reconstructive therapy of peri-implantitis by means of bone graft (and barrier membrane in the test group)

No barrier membrane

Experimental group

Description:

Bone graft will be solely packed in the peri-implantitis bone defect with no membrane to cover

Treatment:

Procedure: Reconstructive therapy of peri-implantitis by means of bone graft (and barrier membrane in the test group)