Recording of Intraoperative Spinal Cord Stimulation and Monitoring

University of California, Los Angeles (UCLA)

Status: Enrolling

Conditions: Disk, Herniated; Spondylosis; Cervical Stenosis

Treatments: Device: epidural electrical stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT05356286

11-000043

Details and patient eligibility

About

Opioid overdose suppresses brainstem respiratory circuits, causes apnea, and may result in death. Epidural electrical stimulation (EES) at the cervical spinal cord facilitated motor activity in rodents and humans, and we hypothesized that EES of the cervical spinal cord could antagonize opioid-induced respiratory depression in humans. In this study, we will stimulate the spinal cord during surgery and assess its effects on respiratory function in human patients.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Any patients undergoing brain or spinal cord surgery where spinal neuromonitoring is utilized.

Exclusion criteria

• none

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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150 participants in 1 patient group

Electrical Stimulation group

Experimental group

Description:

Epidural Electrical Stimulation of the Cervical Spinal Cord

Treatment:

Device: epidural electrical stimulation