Recovery After Sugammadex(Propofol vs Sevoflurane) (Sugammadex2)

Hopital Foch

Status and phase: Completed; Phase 4

Conditions: Anesthesia

Treatments: Drug: Sugammadex

Study type: Interventional

Funder types: Other

Identifiers

NCT01579851

2010-023943-13 (EudraCT Number)

2010/58

Details and patient eligibility

About

Sugammadex is used to reverse of a neuro-muscular block deep. It has been reported that its administration could induce signs of recovery despite continuation of anesthetic drugs. The goal of the present study is to look is the arte of this event is different according to the primary anesthetic agent used.

Enrollment: 71 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients scheduled to receive general anesthesia with muscle relaxation achieved with rocuronium

Exclusion criteria

• Known drug allergy,
• Contra-indications to the use of propofol, remifentanil, rocuronium, sevoflurane, sugammadex
• Difficulty to use Bispectral Index monitor
• Inability to obtain a proper monitoring of muscle relaxation.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

71 participants in 2 patient groups

Propofol-Remifentanil

Active Comparator group

Description:

Anesthesia is maintained with Propofol and Remifentanil; myorelaxation is obtained with rocuronium

Treatment:

Drug: Sugammadex

Sevoflurane-Remifentanil

Active Comparator group

Description:

Anesthesia is maintained with Sevoflurane and Remifentanil; myorelaxation is obtained with rocuronium

Treatment:

Drug: Sugammadex