Rectal Indomethacin Versus Intraperitoneal Lidocaine for Analgesia After Laparoscopic Cholecystectomy

South Valley University

Status: Completed

Conditions: Post-Operative Pain

Treatments: Drug: Lidocaine 2% Injectable Solution; Drug: Indomethacin suppository

Study type: Interventional

Funder types: Other

Identifiers

NCT04964180

analgesia LC

Details and patient eligibility

About

Hospitals, Qena, Egypt in period between May 2020 to May 2021.eighty patients was scheduled to elective laparoscopic cholecystectomy , divided Into two groups randomly using closed envelop method. Group IP lidocaine(40 patients ) received 200 ml saline containing 200 mg 2%lidocaine immediately after abdominal cO2 insufflation( pneumoperitoneum) the surgeon sprayed the total solution on the upper surface of the liver under the right subdiaphragmatic space, left subdiaphragmatic space and around the cholecystectomy site , all patients were maintained in trendelenberg position.

At the end of the laparoscopic procedure, group indomethacin (40 patients) recived two 100 mg indomethacin rectal suppositories 2 hours prior to surgery

Enrollment: 80 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• .ASA physical status 1-2 patients.
• 18-60 years old .

Exclusion criteria

• using or allergic to nonsteroidal anti inflammatory drugs (NSAIDs) or aspirin .
• history of serious hepatic disease.
• renal or gastrointestinal disease.
• bleeding disorder.
• body mass index BMI <18 or ˃30 m2/kg.
• history of abdominal surgery or chronic pain disorder other than gallbladder.
• disease or allergy to lidocaine.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

indomethacin group

Active Comparator group

Description:

group indomethacin (40 patients) recived two 100 mg indomethacin rectal suppositories 2 hours prior to surgery

Treatment:

Drug: Indomethacin suppository

intraperitoneal lidocaine

Active Comparator group

Description:

200 ml saline containing 200 mg 2%lidocaine immediately after abdominal cO2 insufflation( pneumoperitoneum) the surgeon sprayed the total solution on the upper surface of the liver under the right subdiaphragmatic space, left subdiaphragmatic space and around the cholecystectomy site , all patients were maintained in trendelenberg position

Treatment:

Drug: Lidocaine 2% Injectable Solution