Rectus-Intercostal Fascial Plane Block for Liver Transplantation Donors

Istinye University

Status: Enrolling

Conditions: Postoperative Pain; Living Donor; Liver Transplantation

Treatments: Other: Control (No Block); Other: Rectus Intercostal Plane Block

Study type: Interventional

Funder types: Other

Identifiers

NCT07233096

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Details and patient eligibility

About

Postoperative pain control plays a crucial role in enhancing recovery and improving early mobilization in living liver donors. The rectus-intercostal fascial plane (RIFP) block is a novel ultrasound-guided regional anesthesia technique that provides anterior abdominal wall analgesia by targeting the intercostal nerves between the rectus abdominis and intercostal muscle fascia.

This prospective, randomized controlled clinical study aims to evaluate the postoperative analgesic efficacy and opioid-sparing effects of the RIFP block compared with standard intravenous analgesia in living liver donors undergoing donor hepatectomy.

Participants will be randomly assigned to two groups:

Group 1 (RIFP Block): Patients receiving an ultrasound-guided rectus-intercostal fascial plane block using 20 mL of 0.25% bupivacaine at the end of surgery, in addition to standard IV PCA (morphine).

Group 2 (Control): Patients receiving only standard IV PCA (morphine) without regional block.

Full description

This prospective randomized controlled study will include living liver donors undergoing donor hepatectomy. Participants will be divided into two groups: the Rectus-Intercostal Fascial Plane (RIFP) Block Group and the Control Group.

In the RIFP group, patients will receive an ultrasound-guided RIFP block at the end of surgery and postoperative analgesia with intravenous morphine PCA. The control group will receive only intravenous morphine PCA without any regional block.

The primary outcome is total morphine consumption during the first 24 postoperative hours.

Secondary outcomes include pain scores at 1, 6, 12, and 24 hours, time to first rescue analgesia, amount of rescue analgesic used, and incidence of postoperative nausea and vomiting.

This study aims to evaluate the postoperative analgesic efficacy and opioid-sparing effect of the RIFP block in living liver donors compared with standard intravenous analgesia.

Enrollment: 64 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 18 and 75 years
• Patients with American Society of Anesthesiology (ASA) physical status I-II
• Patients scheduled for a living donor hepatectomy

Exclusion criteria

• Allergy to local anesthetics
• Coagulopathy
• Skin infection at the block area
• Advanced renal failure
• Chronic pain syndromes
• Alcohol or drug abuse
• Psychiatric disorders

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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64 participants in 2 patient groups

Rectus Intercostal Plane Block Group

Active Comparator group

Description:

Rectus Intercostal Plane Block Group The patients in the Rectus Intercostal Plane Block group will receive a bilateral rectus intercostal plane block and patient-controlled analgesia (PCA) with morphine for postoperative analgesia.

Treatment:

Other: Rectus Intercostal Plane Block

Control Group

Active Comparator group

Description:

The patients in the Control group will not receive any regional block and will receive PCA with morphine for postoperative analgesia.

Treatment:

Other: Control (No Block)