Recurrent Urinary Tract Infections and the Microbiome

University of Miami

Status: Terminated

Conditions: Recurrent Urinary Tract Infection

Study type: Observational

Funder types: Other

Identifiers

NCT04831840

20201198

Details and patient eligibility

About

The primary objective is to determine if polymerase chain reaction (PCR) (UTIP™) is more sensitive in identifying urinary tract infections (UTI's) than standard urine cultures.

Enrollment: 32 patients

Sex: Female

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 y/o-90 y/o
• Able to consent
• Female
• Group A only: Recurrent UTI (2 UTIs in 6 months)
• Group B only: No history of recurrent UTIs

Exclusion criteria

• Pregnant
• Pelvic radiation
• Urinary retention (>200 ml residual)
• Greater than Stage 2 prolapse
• Renal calculi
• Immunosuppressed
• Neurologic disorder with significant bladder impairment
• No current UTI via dip stick

Trial design

32 participants in 2 patient groups

Female participants with recurrent urinary tract infections (RUTI).

Description:

Patients with RUTIs (Group A) will provide two urine samples. One urine sample is a clean catch and the other is a catheterized specimen. Both will be sent for analysis. A perineal swab will also be collect and analyzed for each patient.

Female control patients without RUTIs

Description:

Patients without RUTIs (Group B) will provide two urine samples. One urine sample is a clean catch and the other is a catheterized specimen. Both will be sent for analysis. A perineal swab will also be collect and analyzed for each patient.