Red Blood Cells as a Reflection of Endothelial Function in Old Age

Heinrich-Heine University, Duesseldorf

Status

Completed

Conditions

Red Blood Cells

Endothelial Function

Nitric Oxide Pool in Red Blood Cells and Blood Plasma

Study type

Observational

Funder types

Other

Identifiers

NCT02265003

14-016

Anaemie

Details and patient eligibility

About

The aim of this study is to find out, how far red blood cells reflect age-depended changes in endothelial function.

Full description

It will be investigated with determination of endothelial function (measured as flow-mediated vasodilation) and of circulated nitric oxid-pool in red blood cells and in blood plasma, how far red blood cells reflect age-depended changes in endothelial function.

Enrollment

140 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Groups 1-3:

Inclusion Criteria:

healthy subjects
informed consent

Exclusion Criteria:

hypertension (blood pressure ≥140/90 mmHg),
hypercholesterolemia (LDL ≥250 mg/dl, HDL ≤45 mg/dl),
diabetes mellitus (fasting plasma glucose ≥128 mg/dl)
acute inflammation (CRP >0.5 mg/dl)
malignant diseases
heart failure (NYHA III-IV)
arrhythmia of high degree
acute or terminated kidney disease
cardiovascular diseases ( cardiac artery disease, peripheral vascular disease and cerebrovascular diseases)
anemia
pregnancy

Group 4 :

Inclusion Criteria:

angiographical signs of apparent atherosclerosis (cardiac artery disease or peripheral vascular disease or degenerative valvular heart disease)
informed consent

Exclusion Criteria:

Hypertension (blood pressure ≥140/90 mmHg),
Hypercholesterolemia (LDL ≥250 mg/dl, HDL ≤45 mg/dl),
Diabetes mellitus (fasting plasma glucose ≥128 mg/dl)
acute inflammation (CRP >0.5 mg/dl)
malignant diseases
heart failure (NYHA III-IV)
arrhythmia of high degree
acute or terminated kidney disease
cardiovascular diseases ( cardiac artery disease, peripheral vascular disease and cerebrovascular diseases)
anemia
pregnancy