Red Cell Distribution Width and Lactate Albumin Ratio as Prognostic Markers for Mortality in Sepsis and Septic Shock

Tanta University

Status: Not yet enrolling

Conditions: Morality; Septic Shock; Sepsis

Treatments: Diagnostic Test: Red cell distribution width; Diagnostic Test: lactate albumin ratio measurement

Study type: Observational

Funder types: Other

Identifiers

NCT05921825

34640/4/12

Details and patient eligibility

About

The aim of this study is to find the utility of red cell distribution width and lactate/albumin ratio as prognostic markers in sepsis and septic shock patients.

Full description

Several indicators are being used to predict the prognosis of sepsis. Commonly used prognostic indicators include Acute Physiological and chronic health evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA), Mortality in Emergency Department Score (MEDS), New York Sepsis severity score.

Red cell distribution Width and lactate albumin ratio are being investigated for there prognostic value in septic patients.

Enrollment: 70 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age from 18 to 60 years old.
2. Clinical criteria of sepsis
3. Or clinical criteria of septic shock including sepsis with persisting hypotension requiring vasopressors to maintain mean arterial pressure > 65 mmHg and having a serum lactate level > 2 mmol/L despite adequate volume resuscitation.

Exclusion criteria

1. No informed consent.
2. Patient with incomplete information and data.
3. The patient who received blood transfusion within 90 days before emergency admission.
4. The patients who are known to have long-term conditions causing anemia like sickle cell anemia, thalassemia, iron deficiency anemia.
5. Malignancy and chemotherapy during the previous 90 days.
6. Patients with either hepatic dysfunction, renal failure, having any disease in which albumin should be supplemented as liver cirrhosis with ascites, nephrotic syndrome and burns.

Trial design

70 participants in 2 patient groups

Non survivors group

Description:

At 28 day, patients were divided into Non survivors group and Survivors group.

Treatment:

Diagnostic Test: lactate albumin ratio measurement

Diagnostic Test: Red cell distribution width

Survivors group

Description:

At 28 day, patients were divided into Non survivors group and Survivors group.

Treatment:

Diagnostic Test: lactate albumin ratio measurement

Diagnostic Test: Red cell distribution width