Redox State in the Course of Chronic Renal Insufficiency and Hemodialysis: Implications in Morbimortality

Public Assistance-Hospitals of Marseille (AP-HM)

Status

Completed

Conditions

Chronic Renal Insufficiency

Treatments

Other: Sampling of blood

Study type

Interventional

Funder types

Other

Identifiers

NCT00684034

2007-38

2007-A01179-44

Details and patient eligibility

About

The influence of hemodialysis on oxidative stress, endothelial activation, inflammation and on the redox state of lymphocytes should be clarified as well as the putative relationships between all these parameters.

Full description

Up to now, no anti-oxydative treatment has been able to reduce the mortality of the patients with Kidney Failure. Thus it is necessary to have a better knowledge of oxydative stress mechanisms in patients with KF in order to find more efficacious treatments. The influence of hemodialysis upon oxidative stress is not well known.

Enrollment

131 patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

18 and 80 years old man or woman dialysing at least 3 times a week for at least 6 months and having no residual renal function
Rate of haemoglobin > 11 g / dl
Clinically stable patient that is having had no considerable event (cardiovascular problem, infection, surgical operation) with the exception of angioplasty of fistula or prosthesis vascular, in the previous 3 months the entrance to the study
Patient capable of understanding and of following the essay, in particular knowing how to read the note of information.

Exclusion criteria

Pregnant woman
Treatment by corticoids or immunosuppresseurs
hemopathy sly
chronic cancer or infection in evolution
Cardiovascular event (infarct, unstable angor, coronary bypasses, confusions of the rhythm, AVC, amputation) or infectious (blood-poisoning, pneumopathie, meningitis) or surgical operation in the previous 3 months the inclusion in the study.