Reduced Carbohydrates + Ketogenic Supplement on Energy Metabolism (SAGE-2)

Université de Sherbrooke

Status

Not yet enrolling

Conditions

Healthy Aging

Treatments

Dietary Supplement: reduced carbohydrate menu combined with ketogenic supplement

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT06455982

2025-5533

Details and patient eligibility

About

The present study will evaluate the effects on glucose, ketones and other blood biomarkers, cognition, quality of life, physical activity and well-being of a reduced carbohydrate diet paired with a ketogenic product for 2 months in a population living in a senior residence. This study follows the KetoHome (fall 2022) and SAGE (fall 2023) projects which assessed the feasibility, acceptability and effectiveness of a reduced carbohydrate intervention alone.

Enrollment

30 estimated patients

Sex

All

Ages

60+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Older men or women in a senior residence;
Understand, read and write French;
Have sufficient visual and hearing acuity to pass cognitive tests;
Available during the intervention period

Exclusion criteria

Body mass index < 20;
T1 diabetic;
T2 insulin-dependent diabetic;
MMSE < 20;
Weight loss >10% in the last 6 months involuntary or voluntary;
Known and uncontrolled hypoglycemia;
Moderate to severe digestive illnesses that can be aggravated by dietary changes;
Severe dysphagia;
Supplementation with MCT oil, ketone salts, ketone esters, adherence to the ketogenic diet, reduced carbohydrate diet, intermittent fasting or other diet or supplements that can significantly increase ketones in the last month;
Participation in other interventional research projects on nutrition or aimed at metabolic change simultaneously.
Medical condition that could prevent the participant from completing the study in the opinion of the doctor