Reduced Dissemination of Tumor Cells With Primary Ligation of the Vein in Patients With Lung Cancer

Sichuan University

Status: Unknown

Conditions: Surgery; Lung Cancer; Circulating Tumor Cell

Treatments: Procedure: Artery ligation first; Procedure: Vein ligation first

Study type: Interventional

Funder types: Other

Identifiers

NCT03436329

TSCI005

Details and patient eligibility

About

The purpose of this study is to assess the impact of the sequence of vessel interruption in lung cancer patients on tumor cell spread and patient survival by using peripheral blood circulating tumor cells.

Full description

Circulating tumor cells (CTCs) in the peripheral blood can be a biomarker to predict tumor recurrence and survival. Handling the tumor during a surgery may promote the release of CTCs into the bloodstream. Therefore, in a surgery of cancer, interruption of the vein before ligation of the artery may be justified. This multi-center randomized controlled trial is to assess the impact of the sequence of vessel interruption in lung cancer patients on tumor cell spread and patient survival by using peripheral blood CTCs.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients with stage I-IV lung cancer eligible for surgery
2. Patients undergoing the completely thoracoscopic lobectomy
3. The nodule size was more than 2.5 cm
4. Patients consenting for intraoperative blood sampling

Exclusion criteria

1. Patients who underwent primary wedge resection and open lobectomy
2. Patients who received neoadjuvant therapy before surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups

Vein ligation first

Experimental group

Description:

During this procedure, patients undergo lobectomy with the pulmonary vein ligated first.

Treatment:

Procedure: Vein ligation first

Artery ligation first

Active Comparator group

Description:

During this procedure, patients undergo lobectomy with the pulmonary artery ligated first.

Treatment:

Procedure: Artery ligation first