Reducing Perioperative S. Aureus Transmission

Randy Loftus

Status: Terminated

Conditions: Health Care Worker Patient Transmission; Health Care Associated Infection; Staphylococcus Aureus

Treatments: Device: Swab and decolonization using povidone-iodine cleansing

Study type: Interventional

Funder types: Other

Identifiers

NCT03638947

201802843

Details and patient eligibility

About

The purpose of this study is to prevent the spread of S. aureus, a dangerous bacterium, within the operating room and between patients undergoing surgery.

Full description

The purpose of this study is to prevent the spread of S. aureus, a dangerous bacterium, within the operating room and between patients undergoing surgery. The investigators will combine several approaches in a "bundle" of activities to achieve this goal. The bundle will include removal of bacterial pathogens from patient skin sites before surgery, from provider hands before, during, and after surgery, from environmental surfaces before and after terminal cleaning, and from the injection ports of patient intravenous catheters. The investigators will use a new surveillance system to evaluate how well the bundle, and each component of the bundle, is working. Surveillance will identify S. aureus transmission events, and movement of S. aureus between reservoirs before, during, and after surgery (perioperative). Surveillance will map transmission events to identify actionable steps to improve the bundle. An infection control perioperative team will act on the surveillance reports to proactively address the action items, and to measure the effect of their efforts for the treatment group. The investigators will compare perioperative S. aureus transmission events for patients receiving the bundle to perioperative S. aureus transmission events for patients receiving usual care.

Enrollment: 236 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• At least 18 years of age
• Undergoing surgery (orthopedic total joint, orthopedic spine, Gynecological/Oncology, thoracic, general, hernia, colorectal, open vascular, plastic surgery and open urological)
• Ability to sign informed consent
• Require general or regional anesthesia

Exclusion criteria

• Less than 18 years of age
• Inability to sign informed consent
• Procedures not included above
• Not requiring general or regional anesthesia

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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236 participants in 2 patient groups

Standard of Care

No Intervention group

Description:

Patient will receive by mail a kit containing swab for the nares, armpit and groin.

Swab kit plus povidone-iodine soap

Active Comparator group

Description:

Patient will receive by mail a kit containing swab for the nares, armpit and groin. In addition the patient will receive decolonization treatment including povidone-iodine soap for presurgical cleansing two days prior to surgery.

Treatment:

Device: Swab and decolonization using povidone-iodine cleansing