Reducing PM-associated CV Health Effects for Seniors

Michigan State University

Status: Completed

Conditions: Cardiovascular Diseases in Old Age

Treatments: Device: Air filtration systems without filters (sham); Device: High efficiency air filtration systems; Device: Low efficiency air filtration systems

Study type: Interventional

Funder types: Other

Identifiers

NCT03334565

R01NR014484

Details and patient eligibility

About

The objective of this study is to investigate the effectiveness of air filtration at reducing personal-level exposures to fine particulate matter (PM2.5) and mitigating related cardiovascular (CV) health effects among older adults in a residential facility in a representative US urban location.

We enrolled 40 nonsmoking older adults into a randomized double-blind crossover intervention study with daily CV health outcomes and PM2.5 exposure measurements. The study was conducted in a low-income senior living apartment building in downtown Detroit, Michigan.

Participants were exposed to three 3-day scenarios separated by one-week washout periods: unfiltered ambient air (control), low-efficiency (LE) "HEPA-type", and high-efficiency (HE) "true-HEPA" filtered air using air filtration systems in the bedroom and main living space of each residence.

The primary outcome was brachial blood pressure (BP). Secondary outcomes included noninvasive aortic hemodynamics and pulse wave velocity and heart rate variability. PM2.5 exposures were measured in the participants' residences as well as by personal-level monitoring.

Enrollment: 40 patients

Sex: All

Ages: 50 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 50 to 85 years old
• non-smoking healthy adults

Exclusion criteria

• smoke or anyone in your residence smokes.
• had a cardiovascular event within the past 6 months (such as myocardial infarction (heart attack), angina, cardiac or carotid surgery or stent, diagnosed peripheral arterial disease, aortic aneurysms, treated heart failure, any treated arrhythmia including atrial fibrillation)
• have renal disease requiring dialysis.
• have had medication changes in the past 6 weeks.
• use supplementary oxygen.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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40 participants in 3 patient groups

Sham

Sham Comparator group

Description:

Participants were exposed to unfiltered ambient air (sham) filtered air using air filtration systems in the bedroom and main living space of each residence.

Treatment:

Device: Air filtration systems without filters (sham)

Low efficiency

Active Comparator group

Description:

Participants were exposed to low-efficiency (LE) "HEPA-type" filtered air using air filtration systems in the bedroom and main living space of each residence.

Treatment:

Device: Low efficiency air filtration systems

High efficiency

Active Comparator group

Description:

Participants were exposed to high-efficiency (HE) "true-HEPA" filtered air using air filtration systems in the bedroom and main living space of each residence.

Treatment:

Device: High efficiency air filtration systems