Reducing Sedentary Time in Patients With Mild Cognitive Impairment: The Take a STAND for Health Study

University of Sao Paulo

Status: Not yet enrolling

Conditions: Mild Cognitive Impairment

Treatments: Behavioral: Take a STAND for health

Study type: Interventional

Funder types: Other

Identifiers

NCT04507386

Take a STAND for Health MCI

Details and patient eligibility

About

This research program aims to comprehensively investigate the clinical, physiological, metabolic, and molecular effects of reducing sedentary behavior in patients with mild cognitive impairment. A 4-month parallel-group randomized controlled trial will be conducted aiming to investigate the feasibility and efficacy of a newly developed personalized intervention focused on replacing sedentary time with light-(or very light-) intensity physical activity in patients with mild cognitive impairment. Additionally, a sub-sample of patients will complete a randomised cross-over study aiming to unravel potential mechanisms underlying the metabolic, physiological and molecular effects of breaking up sedentary time with light-intensity physical activity versus carrying out the minimum amount of daily exercise at once and then remaining sedentary versus simply remaining sedentary throughout all sessions, in a well-controlled laboratorial condition.

Enrollment: 60 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Middle-aged and older adults with mild cognitive impairment confirmed by a team of neurologists from the CEREDIC HC-FMUSP

Exclusion criteria

• Patients who spend less than 8 hours per day in sedentary time
• Patients who are physically active (more than 150 min/week of moderate physical activity, or more than 75 min/week of vigorous activity)
• Patients who are functional illiterates
• Patients with history or clinical diagnosis of neurological diseases
• Patients with severe psychiatric symptoms
• Patients taking antidepressants
• Patients with visual and/or hearing impairments that prevent participation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Take a STAND for health

Experimental group

Description:

A newly developed personalized intervention focused on replacing sedentary time with light-(or very light-) intensity physical activity

Treatment:

Behavioral: Take a STAND for health

Control

No Intervention group

Description:

The control group will receive regular medical care and advice on healthy lifestyle, including physical activity and healthy eating recommendations