Reducing Sedentary Time in Rheumatoid Arthritis: The Take a STAND for Health Study

University of Sao Paulo

Status: Unknown

Conditions: Rheumatoid Arthritis

Treatments: Behavioral: Take a STAND for health

Study type: Interventional

Funder types: Other

Identifiers

NCT03186924

Take a STAND for health RA

Details and patient eligibility

About

This research program aims to comprehensively investigate the clinical, physiological, metabolic, and molecular effects of reducing sedentary behavior in rheumatoid arthritis. To this aim, we will conduct a 4-month parallel-group randomized controlled trial aiming to investigate the feasibility and efficacy of a newly developed personalized intervention focused on replacing sedentary time with light-(or very light-) intensity physical activity in rheumatoid arthritis. Additionally, a sub-sample of patients will complete a randomised cross-over study aiming to unravel potential mechanisms underlying the metabolic, physiological and molecular effects of breaking up sedentary time with light-intensity physical activity versus carrying out the minimum amount of daily exercise at once and then remaining sedentary versus simply remaining sedentary throughout all sessions, in a well-controlled laboratorial condition.

Enrollment: 30 estimated patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Post-menopausal women diagnosed with rheumatoid arthritis

Exclusion criteria

• any physical disabilities that preclude physical exercise testing
• participation in structured exercise training programs within the last 12 months
• unstable dose of disease modifying drugs, including biological therapy, in the last 3 months prior to and during the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

Take a STAND for health

Experimental group

Description:

A newly developed personalized intervention focused on replacing sedentary time with light-(or very light-) intensity physical activity

Treatment:

Behavioral: Take a STAND for health

Control

No Intervention group

Description:

The control group will receive all regular medical care and advice on healthy lifestyle, including the promotion of recommended physical activity levels and health nutrition.