Reducing Suicidal Ideation Through Treatment of Nightmares-Post Traumatic Stress Disorder (PTSD) (REST-ON PTSD)

Augusta University

Status and phase: Completed; Phase 4

Conditions: Suicidal Ideation; Post Traumatic Stress Disorder; Nightmares

Treatments: Drug: Prazosin; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02199652

00001365

Details and patient eligibility

About

Patients with PTSD, and frequent nightmares, and mild-moderate suicidal ideation, who are already taking a Selective Serotonin Reuptake Inhibitor (SSRI) or Serotonin Norepinephrine Reuptake Inhibitor (SNRI) will be randomized to either prazosin or placebo. The investigators hypothesize that patients receiving prazosin will have a greater reduction in suicidal ideation.

Enrollment: 20 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• PTSD
• Frequent nightmares
• Suicidality

Exclusion criteria

• Schizophrenia
• Bipolar
• Substance abuse

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups, including a placebo group

placebo

Placebo Comparator group

Description:

placebo pill

Treatment:

Drug: Placebo

prazosin

Experimental group

Description:

prazosin pill

Treatment:

Drug: Prazosin