Reduction of Asthma Exacerbation Rate in Children by Non-invasive Monitoring of Inflammatory Markers in Exhaled Breath (Condensate): the RASTER Study

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Asthma; Non-invasive Inflammatory Markers; Home Monitoring; Volatile Organic Compounds; Children; Exhaled Breath Condensate

Study type: Observational

Funder types: Other

Identifiers

NCT01239238

10-2-064

Details and patient eligibility

About

The purpose of the present proposal was to investigate the predictive properties of markers in exhaled breath to predict an asthma exacerbation. In addition, the reliability of home monitor assessments to measure asthma control will be examined.

Enrollment: 102 patients

Sex: All

Ages: 6 to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. already known with a diagnosis of asthma during at least 6 months
2. age between 6 and 17 years
3. reversibility to a bronchodilator (increase in FEV1 > 9% of predicted value and/or
4. bronchial hyperresponsiveness to histamine < 8 mg/ml.

Exclusion criteria

1. cardiac abnormalities
2. mental retardation, congenital abnormalities or existence of a syndrome
3. active smoking
4. no technical satisfactory performance of measurements
5. no phone line or internet assess available at home.

Trial design

102 participants in 1 patient group

Care as usual

Description:

Therapy is guided based on symptoms and lung function. Assessments: home monitoring, symptoms, lung function, FeNO, asthma control, quality of life and diagnostic assessments of non-invasive inflammatory markers in exhaled air and exhaled breath condensate.