Reduction of Myocardial Infarction by Preconditioning in Patients With Ruptured Abdominal Aortic Aneurysm (PreconRAAA)

Nikolaj Eldrup

Status: Completed

Conditions: Abdominal Aortic Aneurysm

Treatments: Procedure: Precondition

Study type: Interventional

Funder types: Other

Identifiers

NCT00883363

NE_RAAA_PRECON_01

Details and patient eligibility

About

Preconditioning in patients treated for elective abdominal aneurysm showed that the rate of perioperative myocardial infarction could be reduced by 80 %(ARR from 27% to 5%). Precondition where performed by 10 minutes of clamping of each iliac arteries before clamping the abdominal aorta. Human studies in cardiac patients have shown promising results with precondition. Instead of clamping arteries they have all performed the procedure by inflating a blood pressure cuff above arterial pressure on a arm.

The investigators want to investigate if preconditioning induced by a blood pressure cuff on a arm can reduce the perioperative rate of myocardial infarction in patients open operated for ruptured abdominal aortic aneurysm.

Enrollment: 200 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with ruptured abdominal aortic aneurysm offered surgery
• Age > 18 years

Exclusion criteria

• Technical inoperable

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 2 patient groups

Precondition

Experimental group

Description:

Induction of precondition at start of operation on a arm

Treatment:

Procedure: Precondition

Control

No Intervention group

Description:

No precondition