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Reduction of Sperm DNA Fragmentation by Oral Ginger

R

Royan Institute

Status and phase

Completed
Phase 2

Conditions

Infertility

Treatments

Drug: Placebo
Drug: oral administration of ginger

Study type

Interventional

Funder types

Other

Identifiers

NCT02032251
royan-Emb-017

Details and patient eligibility

About

This study is a randomized, double blind, controlled clinical trials assess the efficacy of the ginger oral treatment on sperm DNA fragmentation, sperm parameters and male hormones.

Full description

Sperm DNA fragmentation is known to affect male fertility. Previous findings have suggested the implication of oxidative stress in the etiology of this pathological condition. The present study was designed to find out DNA fragmentation in ejaculated spermatozoa can be reduced by oral treatment with Ginger extract. 71 men with unexplained or Idiopathic infertility were randomized between a Ginger treatment (500 milligram daily for 3months) group and a placebo group.

Sperm DNA fragmentation was evaluated by Terminal deoxyribonucleotidyltransferase-mediated dUTP nick-end labeling assay (TUNEL) before and after treatment. No differences in basic sperm parameters were found between the Ginger treatment and the placebo group before or after treatment. However, the percentage of DNA-fragmented spermatozoa was markedly reduced (P< .005) in the Ginger treatment group after the treatment as compared with the pretreatment values). No difference in the pretreatment and post treatment incidence of sperm DNA fragmentation was observed in the placebo group. These data show that sperm DNA damage can be efficiently treated with oral Ginger extract administered during a relatively short time period.

Enrollment

71 patients

Sex

Male

Ages

20 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • men with idiopathic infertility or unexplained

Exclusion criteria

  • history of varicocele, genitourinary inflammation or infection
  • history of cigarette smoking.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

71 participants in 2 patient groups, including a placebo group

ginger
Experimental group
Description:
The patients with infertility that underwent oral administration of ginger.
Treatment:
Drug: oral administration of ginger
Placebo
Placebo Comparator group
Description:
The patients with infertility that receive placebo.
Treatment:
Drug: Placebo

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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