Reduction Ratio and Clearance During Hemodialysis With MCO-filter Compared to HDF With Standard High-flux Filter

Region Skane

Status: Completed

Conditions: Chronic Kidney Failure; Dialysis; Uremia

Treatments: Device: High-flux HDF; Device: MCO-HD

Study type: Interventional

Funder types: Other

Identifiers

NCT03437538

2017/830/1

Details and patient eligibility

About

The Medium Cut-Off dialysis (MCO) membrane has been developed to improve middle molecule removal compared to standard high-flux dialysis filters.

The major aim of this study is to compare the reduction ratio of middle molecules, during a single hemodialysis session with MCO-filter, compared to hemodiafiltration (HDF) with standard high-flux filter.

Secondary aims are to compare the reduction ratio of small and large molecules between the treatments.

Enrollment: 18 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ongoing HDF treatment
• CRP <30
• No Acute Myocardial Infarction within 3 months.

Exclusion criteria

• Not able to understand the study information.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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18 participants in 2 patient groups

First MCO-HD, then High-flux-HDF

Active Comparator group

Description:

Participants with ongoing HDF-treatments will have measurements during an intervention with a 4h dialysis with MCO-HD, followed by 2 weeks of washout with ordinary HDF, thereafter measurements during a 4h dialysis with High-flux-HDF

Treatment:

Device: High-flux HDF

Device: MCO-HD

First High-flux-HDF, then MCO-HD

Active Comparator group

Description:

Participants with ongoing HDF-treatments will have measurements during a 4h dialysis with High-flux-HDF, followed by 2 weeks of washout with ordinary HDF, thereafter measurements during an intervention with a 4h dialysis with MCO-HD

Treatment:

Device: High-flux HDF

Device: MCO-HD