Regeneration of Immature Teeth. Case Series

J

Jordan University of Science and Technology

Status

Active, not recruiting

Conditions

Revascularization

Treatments

Procedure: Triple paste and induced bleeding
Drug: Triple Paste metronidazole, ciprofloxacin and minocycline mixed with sterile glycol

Study type

Interventional

Funder types

Other

Identifiers

NCT03507556
JordanUST1

Details and patient eligibility

About

This clinical study aims to investigate the predictability of revascularization procedure of immature necrotic human permanent teeth with apical periodontitis. The quality of root development (thickness and length) will be assessed radiographically.

Full description

All teeth will be disinfected using either triple antibiotic paste (a mixture of metronidazole, ciprofloxacin and amoxicillin mixed with sterile glycole) or non setting calcium hydroxide applied to the pulp space with a sterile lentulospiral and then closed temporarily with a sterile sponge and temporary restoration for 2-3 weeks to allow disinfection of the canals teeth will be reentered under rubber dam isolation and all intracanal medicaments will be washed out from the canal using 10 ml of 2.5% sodium hypochlorite and 20 ml of Ethylene diamine tetra acetic acid (EDTA). Then, a sterile endodontic file will be inserted past the canal terminus into the periapical tissues to induce bleeding to fill the canal space as much as possible and subsequently sealed with a double coronal seal using bioceramic repair material and composite filling. All the teeth will be monitored clinically and radiographically on a biannual basis.

Enrollment

40 estimated patients

Sex

All

Ages

6 to 20 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. Teeth diagnosed with necrotic pulp with/without evidence of apical periodontitis.
  2. An immature/open apex.
  3. Tooth does not need post and core restoration.
  4. Medically healthy patients with no known allergy to used materials.

Exclusion criteria

  1. Medically compromised patient,
  2. Teeth with periodontal involvement
  3. Teeth with vertical root fractures,
  4. Non-restorable teeth,

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

40 participants in 1 patient group

Triple paste and induced bleeding
Experimental group
Description:
The triple paste is a mixture of metronidazole, ciprofloxacin and minocycline mixed with sterile glycol will be used and next visit intracanal bleeding will be induced
Treatment:
Drug: Triple Paste metronidazole, ciprofloxacin and minocycline mixed with sterile glycol
Procedure: Triple paste and induced bleeding

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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