Regenerative Endodontic Treatment of Mature Necrotic Teeth With Apical Periodontitis

Cairo University (CU)

Status: Completed

Conditions: Apical Periodontitis; Necrotic Pulp

Treatments: Other: White MTA; Other: Biodentine

Study type: Interventional

Funder types: Other

Identifiers

NCT04018456

CU-2019-7-7

Details and patient eligibility

About

The aim of this prospective, randomized, controlled double-blind study is to evaluate the effectiveness of biodentine compared with MTA used as pulp space barrier on discoloration of teeth after regenerative based non-obturation root canal treatment in mature single canal with pulp necrosis and apical periodontitis.

Full description

• Regenerative endodontic treatment will be performed through two visits: First visit aims to clean and disinfect the tooth canal by copious irrigation with NaOCL and EDTA solution . At the end of first visit, canal will be dressed by CaOH as intracanal medicaments.

Second visit will be after two weeks. After removal of CaOH dressing by copius irrigation, evoking bleeding inside canal by over instrumentation. When blood become semi-coagulated, according to the random sequence number of the participants, either biodentine or white MTA will be placed as pulp space barrier.

At the end of treatment, the access cavity will be sealed with composite restoration.

Enrollment: 36 patients

Sex: All

Ages: 10 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Tooth type: single-rooted teeth (anterior or premolar) encasing of one root canal with mature root (closed apex).
2. Negative response of pulp tissue to electrical or thermal pulp tester.
3. Widening in lamina dura or periapical radiolucency not more than 3 mm.

Exclusion criteria

• 1. Patients having significant systemic disorder or immunocompromised patients. 2. Teeth with generalized chronic periodontitis or have periodontal pocket larger than 3 mm.

  2. Teeth with developmental anomalies (i.e, dens invaginatusor a palatogingival groove).

  3. Teeth with previous root canal. 5. Teeth need to post and core as final restoration

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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36 participants in 2 patient groups

Biodentine

Experimental group

Description:

Intervention group: application of biodentine as pulp space barrier during regenerative endodontic treatment.

Treatment:

Other: Biodentine

White MTA

Active Comparator group

Description:

Control group: application of White MTA as pulp space barrier during regenerative endodontic treatment.

Treatment:

Other: White MTA