Regenerative Medicine of Articular Cartilage: Characterization and Comparison of Chondrogenic Potential and Immunomodulatory Adult Mesenchymal Stem Cells (ARTHROSTEM)

Nantes University Hospital (NUH)

Status: Completed

Conditions: Knee Osteoarthritis

Treatments: Procedure: arthroplasty

Study type: Interventional

Funder types: Other

Identifiers

NCT01879046

RC12_0394

Details and patient eligibility

About

Articular cartilage can be the seat of many diseases including osteoarthritis and traumatic defaults. The cartilage has no intrinsic ability to repair resulting at long term in function loss in the joints. Currently available treatments are not satisfactory in the long term, the use of mesenchymal stem cells appears to be promising due to their ability to multipotency and immunomodulation properties. This project aims to determine the most appropriate source for regenerative medicine of cartilage stem cells from tissue taken during arthroplasty in patients with osteoarthritis. These cells will be tested for different chondrogenic markers. The success of this project will consider the implementation of a strategy for regenerative medicine in bone and joint diseases.

Enrollment: 35 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged over 18 years
• Patients with knee osteoarthritis
• Patients requiring total knee arthroplasty
• Patients who signed the consent form

Exclusion criteria

• Patients aged less than 18 years
• Major Patients under guardianship
• Pregnant woman
• Infectious pathology or progressive tumor
• Refusal to participate in the study
• State of immunosuppression
• Congenital or acquired malformation resulting in a deformation of the knee

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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35 participants in 1 patient group

Surgical intervention

Experimental group

Description:

Blood, bone marrow and Hoffa's fat pad samplings during surgical intervention

Treatment:

Procedure: arthroplasty