Regenerative Therapy With Autologous Stromal Vascular Fraction Derived Mesenchymal Stem Cells and Platelet-rich Plasma to Treat Complex Perianal Diseases

Kantonsspital Winterthur KSW

Status: Not yet enrolling

Conditions: Perianal Crohn Disease; Anal Fissure; Perianal Fistula; Perianal Fistula Due to Crohn's Disease; Rectovaginal Fistula

Treatments: Procedure: Regenerative therapy with SVF-PRP to supplement perianal surgery

Study type: Observational

Funder types: Other

Identifiers

NCT05709717

SVF-PRP

Details and patient eligibility

About

Consecutive patients with complex anal fistula were prospectively followed for 12 months. Routine MRI was performed before and at 4 and 12 months after surgery. Continence was assessed likewise using a validated questionnaire. Fistula were drained with setons prior surgery. SVF was harvested from subcutaneous abdominal fat and PRP from peripheral blood. Distal fistulectomy to the sphincter was performed and the wound left open, while the internal orifice was closed. SVF-PRP was injected around the fistula. Patients showered their excision wound until dry. Outcomes were reported as median & interquartile range (IQR)

Enrollment: 50 estimated patients

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Perianal fistula Perianal fissure Anovaginal fistula Rectovaginal fistula Perianal Crohn's disease

Exclusion criteria