Regional Activation of Leukocytes in Coronary Artery Disease (REAL-CAD)

Sint Franciscus Gasthuis

Status: Completed

Conditions: Coronary Artery Disease; Inflammation

Study type: Observational

Funder types: Other

Identifiers

NCT02376738

REAL-CAD

Details and patient eligibility

About

This study aims to evaluate the role of leukocyte activation in coronary artery disease

Full description

1. The primary aim of REAL CAD is to determine regional differences of leukocyte activation in different vascular beds in vivo.
2. The secondary aim is to investigate differences in leukocyte activation between diabetic and CAD subjects and patients suffering from both.
3. The third aim is to investigate the relationship between complement components, triglycerides and leukocyte activation markers in order to gain more insight into the causative processes leading to activation of leukocytes.
4. The fourth aim is to get more insight in the MBL genotypes and serum levels of CAD and/or diabetic patients and the 'healthy' groups included in our study.

Enrollment: 97 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects scheduled to undergo a coronary catheterization
• Provide written informed consent
• Aged >18 and <75 years
• BMI < 35 kg/m2

Exclusion criteria

• Emotionally and intellectually not capable to decide about participation in the study and the consequences of participation. Subjects who are not able to understand the patient information
• CRP > 20 mg/l
• Unstable angina pectoris
• CABG or PTCA during the last 6 months
• Alcohol use > 2 units/day
• Aberrations in kidney, liver and thyroid function
• Use of any experimental medication within 6 months of the catheterization
• The use of immunosuppressive drugs