Regional Citrate Anticoagulation in Plasma Exchange Treatment

University Medical Centre Ljubljana

Status: Completed

Conditions: Guillain-Barre Syndrome; Focal Segmental Glomerulosclerosis

Treatments: Procedure: plasma exchange treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT01370200

111/09/09

Details and patient eligibility

About

The investigators want to compare the efficacy of plasma exchange treatment with using two different citrates ( 4% and 15% ) as anticoagulants in plasma exchange treatment.

The efficacy of plasma exchange treatment is better with using 15% trisodium citrate as anticoagulant during the plasma exchange procedure.

Full description

To compare the elimination rate of immunoglobulins in plasma exchange treatment by using two differently concentrated citrates for anticoagulation during plasma exchange procedure. At the same time we want to compare acid-base , electrolyte status and anticoagulation protocol in two citrate groups.

Enrollment: 140 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who need plasma exchange treatment
• human albumins as a replacement fluid

Exclusion criteria

• anemia Hb less than 90

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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140 participants in 2 patient groups

4% citrate

Active Comparator group

Description:

4% trisodium citrate, starting infusion rate 180 ml/h Interventions according to postfilter ionized calcium, change in 10 ml/h step

Treatment:

Procedure: plasma exchange treatment

15% citrate

Active Comparator group

Description:

15% trisodium citrate, starting infusion rate 50 ml/h Interventions according to postfilter ionized calcium, change in 10 ml/h step

Treatment:

Procedure: plasma exchange treatment