Registry of Right-to-left Shunt Detection by Contrast-enhanced Transcranial Doppler in Chinese Population

Y

Yingqi Xing

Status

Completed

Conditions

Cerebral Infarction
Migraine
Right-to-left Shunt

Study type

Observational

Funder types

Other

Identifiers

NCT02425696
RLS-1dzx

Details and patient eligibility

About

The purpose of the study is to evaluate the prevalence and extent of right-to-left shunt (RLS) in Chinese migraineurs, and the morbidity of silent cerebral infarction in migraineurs.

Full description

This is a prospective multicenter study of Chinese population. Participants (normal individuals without migraine and migraineurs) are included after standardized diagnostic procedures (TCD and c-TCD). For migraineurs with large RLS further examinations (c-TTE and brain MRI) are required. Up to 10 study sites nationwide will be needed to recruit the planned participant population during a 1-year period. The information of each participants will be registered, including basic facts, the longitudinal headache history, frequency, location, quality, intensity, duration, accompanied symptoms, precipitating and exacerbating factors, with or without aura, MIDAS and HIT-6 questionnaire.

Enrollment

1,100 patients

Sex

All

Ages

16 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • For group 1: Normal healthy individual without migraine.
  • For group 2: Clinical history of migraine diagnosed by a neurologist according to the International Classification of Headache Disorders.

Exclusion criteria

Subjects with stenotic intracranial or extracranial arteries or intracranial abnormalities diagnosed with TCD.

Trial design

1,100 participants in 2 patient groups

group 1
Description:
Normal individuals without migraine
group 2
Description:
Migraineurs

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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