Regorafenib in Relapsed Glioblastoma (REGOMA)

Istituto Oncologico Veneto IRCCS

Status and phase

Completed

Phase 2

Conditions

Glioblastoma Multiforme

Treatments

Drug: Lomustine

Drug: Regorafenib

Study type

Interventional

Funder types

Other

Identifiers

NCT02926222

2014-003722-41 (EudraCT Number)

IOV-GB-1-2014 REGOMA

Details and patient eligibility

About

This study aims to evaluate the role of Regorafenib in prolonging the overall survival of glioblastoma multiforme patients who progressed after surgery and Stupp regimen with or without bevacizumab.

Full description

The primary aim of the study is to evaluate the overall survival (OS) in the intention to treat (ITT) population. Secondary aims are to evaluate the progression free survival (PFS), safety, objective response rate (ORR), disease control rate (DCR) in the ITT population, and the evaluation of quality of life (QoL). Additional exploratory objectives include the analysis of antiangiogenic and metabolic biomarkers in tissue at first and second surgery (if performed) by the evaluation of certain metabolic features of tumors that could be involved in tumor responses to antiangiogenic drugs.

Enrollment

119 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Male or female ≥ 18 years of age
Histologically confirmed de novo glioblastoma multiforme (grade IV)
First recurrence after adjuvant treatment (surgery followed by radiotherapy and temozolomide chemotherapy with or without bevacizumab) in patients who have not received further therapeutic interventions
For patients not undergoing a second surgery at the time of relapse, recurrent disease must include at least one bi-dimensionally measurable contrast-enhancing lesion with clearly defined margins by MRI scan, with minimal diameters of 10 mm, visible on 2 or more axial slices 5 mm apart, based on an MRI scan done within 2 weeks prior to randomization
Documented progression of disease as defined by RANO criteria at least 12 weeks after completion of radiotherapy, unless the recurrence is outside the radiation field or has been histologically documented
Have adequate bone marrow function, liver function, and renal function, as measured by the following laboratory assessments conducted within 7 days prior to the initiation of study treatment:
- Hemoglobin >9.0 g/dl
- Absolute neutrophil count (ANC) >1500/mm3 without transfusions or granulocyte colony stimulating factor and other hematopoietic growth factors
- Platelet count ≥100,000/μl
- White blood cell count (WBC) >3.0 x 109/L
- Total bilirubin <1.5 times the upper limit of normal
- ALT and AST <3 x upper limit of normal (<5 x upper limit of normal for patients with liver involvement of their cancer and/or have bone metastasis)
- Serum creatinine <1.5 x upper limit of normal
- Alkaline phosphatase <2.5 x ULN (<5 x upper limit of normal for patients with liver involvement of their cancer and/or have bone metastasis)
- PT-INR/PTT <1.5 x upper limit of normal (Patients who are being therapeutically anticoagulated with an agent such as coumadin or heparin will be allowed to participate provided that no prior evidence of underlying abnormality in these parameters exists per medical history)
- Lipase ≤ 1.5 x the ULN
Glomerular filtration rate ≥ 30 mL/min/1.73 m2 according to the Modified Diet in Renal Disease abbreviated formula
Analyses of MGMT methylation status on tumoral tissue at first surgery (at own institution)
Understand, be willing to give consent, and sign the written informed consent form (ICF) prior to undergoing any study-specific procedure
If female and of childbearing potential, have a negative result on a pregnancy test performed a maximum of 7 days before initiation of study treatment
If female and of childbearing potential, or if male, agree to use adequate contraception (eg, intrauterine device, oral contraceptive, or double-barrier method) based on the judgment of the investigator or a designated associate from the date on which the ICF is signed until 8 weeks after the last dose of study drug
World Health Organization (WHO) Performance status ≤ 1 (or Karnofsky performance status (KPS) ≥70)) within 14 days prior to the initiation of study treatment
Stable or decreasing dosage of steroids for 7 days prior to the baseline MRI scan.
Patients may have undergone surgery for the recurrence; the histological report must document a glioblastoma recurrence. If operated:
- at least 28 days and maximum 42 days interval from the surgery is required prior to administration of study drugs and patients should have fully recovered
- Exclusion Criteria:
Are taking strong cytochrome P (CYP) CYP3A4 inhibitors (eg, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telithromycin, voriconazole) or strong CYP3A4 inducers (eg, carbamazepine, phenobarbital, phenytoin, rifampin, St. John's Wort)
Radiotherapy within 12 weeks prior to the diagnosis of progression, if the lesion is in the radiation field,
Have had systemic anticancer therapy including cytotoxic therapy, signal transduction inhibitors, immunotherapy, and/or hormonal therapy within 4 weeks prior to initiation of study treatment
Positioning of carmustin wafers during first or second surgery
Other active or inactive malignancy (except for carcinoma in situ of the cervix, of the prostate or basal cell carcinoma). Malignancy will be considered inactive if patients are in complete remission for at least 3 years prior to study entry
Have had prior treatment with regorafenib or any other VEGFR-targeting kinase inhibitor
Have had a major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to initiation of study treatment
Are pregnant
Are breastfeeding
Are unable to swallow oral tablets (crushing of study treatment tablets is not allowed)
Have congestive heart failure classified as New York Heart Association Class 2 or higher
Have had unstable angina (angina symptoms at rest) or new-onset angina ≤ 3 months prior to screening.
Have had a myocardial infarction < 6 months prior to initiation of study treatment
Have cardiac arrhythmias requiring anti-arrhythmic therapy, with the exception of beta blockers or digoxin
Have uncontrolled hypertension (systolic blood pressure [SBP] > 140 mmHg or diastolic blood pressure [DBP] > 90 mmHg) despite optimal medical management
Have had arterial thrombotic or embolic events such as cerebrovascular accident (including transient ischemic attacks), or pulmonary embolism within 6 months prior to the initiation of study treatment
Have an ongoing infection with severity of Grade 2 or above (NCI-CTCAE v 4.0)
Have a known history of human immunodeficiency virus infection
Have either active or chronic hepatitis B or C requiring treatment with antiviral therapy
Have a history of organ allograft
Have evidence or history of any bleeding diathesis (including mild hemophilia), irrespective of severity
Have had a hemorrhage or a bleeding event ≥ Grade 3 (NCI-CTCAE v 4.0) within 4 weeks prior to the initiation of study treatment
Have a non-healing wound, ulcer, or bone fracture
Have renal failure requiring hemodialysis or peritoneal dialysis
Have dehydration ≥ Grade 1 (NCI-CTCAE v 4.0)
Have interstitial lung disease with ongoing signs and symptoms at the time informed consent is obtained
Have persistent proteinuria > 3.5 g/24 hours measured by urine protein creatinine ratio from a random urine sample (Grade 3, NCI-CTCAE v 4.0)
Have any other serious or unstable illness, or medical, psychological, or social condition, that could jeopardize the safety of the subject and/or his/her compliance with study procedures, or may interfere with the subject's participation in the study or evaluation of the study results
Have a known hypersensitivity to any of the study drugs, study drug classes, or excipients in the formulation of the study drugs
Have any malabsorption condition
Recurrent disease located outside of the brain