Regular Physical Exercise Extends Honeymoon Phase in Type 1 Diabetes Subjects


University Hospital A Coruña




Physical Activity
Type 1 Diabetes

Study type


Funder types




Details and patient eligibility


In diabetes, the honeymoon period is characterized by the presence of a functional reserve of β-cells that favours an adequate metabolic control and low insulin needs in order to control glycaemia. Therefore, the extension of this period could have evident benefits in diabetes management. The investigators aimed to study the influence of regular physical activity on the prolongation of the honeymoon period

Full description

Observational study of two groups of type 1 diabetic patients from onset to a two-year period. One group exercised regularly (5 or more hours/week) before onset and continued doing so with the same regularity (group A). The second group either did not perform physical activity or did so sporadically (group S). Consultations were initially performed on a weekly basis for the first month, then once a month for the remaining period. In each consultation, patients were asked about diet accomplishment, glycaemia monitoring, insulin injections and exercise performance. All individuals from group A declared to practice regularly intervallic routines, playing team sports (basketball for n=1 and soccer for n=6). Only one individual declared to perform aerobic exercise (long distance running and swimming). At the end of the first year a second blood sample was extracted in the same conditions from each individual to determine the same parameters. Exercise routine accomplishment and follow-up of diet and insulin injections was followed monthly during one more year. At the end of this period, the study was considered finished and the last blood extraction was performed in order to measure the same parameters. Other subjects were excluded because they were not capable to provide data required for study follow up.


19 patients




7 to 30 years old


No Healthy Volunteers

Inclusion criteria

  • Undergo type 1 diabetes.
  • To practice a moderate-vigorous exercise during 1h, 5 days or more/week before onset and continuing practicing for 2 more years for group A (active).
  • To practice any or less than 5h weekly before and after onset for group S (sedentary).
  • Capable to provide data and blood samples during follow up.

Exclusion criteria

  • Not capable to provide data and blood samples required for study follow up.

Trial design

19 participants in 2 patient groups

Group S (sedentary)
Group S included patients that did not perform any physical activity at the moment of onset, continuing with the same habits during the subsequent observational period.
Group A (active)
The inclusion criteria for group distribution took in account the principles of the American College of Sports Medicine, considering as active physical activity to practice a moderate-vigorous exercise during 1h, 5 days or more/week. In this context, a sedentary or less active person should be a person that practices any or less than 5h weekly

Trial contacts and locations



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