Regulation and Signaling of Red Blood Cell (RBC) Endothelial Nitric Oxide Synthase (eNOS) in Patients With Stable and Unstable Coronary Artery Disease

Heinrich-Heine University, Duesseldorf

Status

Completed

Conditions

Coronary Artery Disease

Endothelial NO-synthase

Study type

Observational

Funder types

Other

Identifiers

NCT02265016

RBC in CAD

13-037 (Other Identifier)

Details and patient eligibility

About

The aim of this study is measurement of expression and activity of RBC eNOS in different clinical cohorts of patients with coronary artery disease and acute coronary syndrome and to investigate the importance of the NO-stimulated reaction cascade in terms of sGC and PKG.

Enrollment

300 patients

Sex

All

Ages

40 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

informed consent
for ACS(acute coronary syndrome)-Group: angiographic coronary artery disease; acute coronary syndrome, defined by EITHER unstable angina pectoris with significant coronary stenosis (troponin negative, without significant ST-elevation) OR low-risk NSTEMI (Troponin positive, without significant ST-elevation)
for stable CAD-Group: angiographic coronary artery disease; no acute coronary syndrome within the last 3 months
healthy control group: No clinical or angiographical signs of apparent atherosclerosis

Exclusion criteria

acute inflammation (CRP > 1 mg/dl, leukocyte > 11.000/µl)
malignant diseases
pregnancy
medication with NO-donors ( e.g.isosorbide mononitrate, isosorbide dinitrate, glyceryl trinitrate, Molsidomin, Ranexa)
patients with STEMI or high-risk NSTEMI