Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading

Bispebjerg Hospital

Status and phase: Completed; Early Phase 1

Conditions: Osteoarthritis; Exercise

Treatments: Other: Non Exercise; Other: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT01090375

H-KF-306126

Details and patient eligibility

About

In the present study the microdialysis method is used to investigate biochemical changes within and around the joint simultaneously in both the resting state and in a joint that had been subjected to exercise. The aim of the present study was, by applying the microdialysis technique, to monitor markers of cartilage breakdown and inflammation in 2 different positions of the knee (inside and in the inner part of the knee capsule) in a group of human females with knee osteoarthritis over a period of 3 hours.

Sex: Female

Ages: 55 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• verified osteoarthritis (x-ray)of the knee, female,

Exclusion criteria

• dementia, inflammatory diseases, regular pain medication

Trial design

0 participants in 2 patient groups, including a placebo group

Exercise

Experimental group

Treatment:

Other: Exercise

Non Exercise

Placebo Comparator group

Treatment:

Other: Non Exercise