Regulation of Metabolism and Ion Handling

Morten Hostrup, PhD

Status: Completed

Conditions: Healthy

Treatments: Behavioral: Speed endurance training

Study type: Interventional

Funder types: Other

Identifiers

NCT03317704

SET-NAC

Details and patient eligibility

About

This study investigates the relation between ion-handling (K+) and fatigue development during exercise. Before and after a 6-week period of high intensity interval training, performance and ion-handling is assessed in young adults. In addition, mitochondrial function is examined.

Enrollment: 30 patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy men
• 45-55 ml/kg/min
• BMI 19-26 kg/m2
• Normal ECG (assessed by MD)

Exclusion criteria

• Allergic to n-acetylcystine (NAC) or digoxin
• Severe side effects from NAC or digoxin
• Chronic diseases (assessed by MD to be a potential hazard or to interfere with outcome measures)

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 3 patient groups

speed endurance training (SET)

Active Comparator group

Description:

Training 6 weeks 3 times pr. week

Treatment:

Behavioral: Speed endurance training

Controls

No Intervention group

Description:

Asked to continue their usual life style

speed endurance training (SET) II

Active Comparator group

Description:

Training 6 weeks 3 times pr. week

Treatment:

Behavioral: Speed endurance training