Regulatory B Cells and Chronic Immune Thrombocytopenia (PTIREG)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Purpura, Thrombocytopenic, Idiopathic; Regulatory B Cells

Treatments: Biological: Biological tests

Study type: Observational

Funder types: Other

Identifiers

NCT02891109

PTIREG

Details and patient eligibility

About

The chronic immune thrombopenia is an autoimmune disease caused by B cells. These cells produce anti platelets and megakaryocytes antibodies. Some B cells, named regulatory B cells, are known to control other cells. Their action in chronic immune thrombopenia is actually unknown.

Full description

The chronic immune thrombopenia is an autoimmune disease caused by B cells. These cells produce anti platelets and megakaryocytes antibodies. Some B cells, named regulatory B cells, are known to control other cells. Their action in chronic immune thrombopenia is actually unknown. In our cohort of chronic immune thrombopenia and controls, we realized a flow cytometry analyze of B and T cells and a co-culture to determine regulatory B cells functionality.

Enrollment: 36 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Purpura, Thrombocytopenic, Idiopathic, chronic phase (>12 months)
• no treatment or thrombopoietin receptor agonists

Exclusion criteria

• < 18 years
• Purpura, Thrombocytopenic, Idiopathic, acute phase
• pregnancy
• others causes of thrombopenia

Trial design

36 participants in 2 patient groups

patients group

Description:

Adults patients with chronic immune thrombocytopenia

Treatment:

Biological: Biological tests

control group

Description:

Adults without immune thrombocytopenia

Treatment:

Biological: Biological tests