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Regulatory B Cells and Chronic Immune Thrombocytopenia (PTIREG)

R

Regional University Hospital Center (CHRU)

Status

Completed

Conditions

Purpura, Thrombocytopenic, Idiopathic
Regulatory B Cells

Treatments

Biological: Biological tests

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

The chronic immune thrombopenia is an autoimmune disease caused by B cells. These cells produce anti platelets and megakaryocytes antibodies. Some B cells, named regulatory B cells, are known to control other cells. Their action in chronic immune thrombopenia is actually unknown.

Full description

The chronic immune thrombopenia is an autoimmune disease caused by B cells. These cells produce anti platelets and megakaryocytes antibodies. Some B cells, named regulatory B cells, are known to control other cells. Their action in chronic immune thrombopenia is actually unknown. In our cohort of chronic immune thrombopenia and controls, we realized a flow cytometry analyze of B and T cells and a co-culture to determine regulatory B cells functionality.

Enrollment

36 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Purpura, Thrombocytopenic, Idiopathic, chronic phase (>12 months)
  • no treatment or thrombopoietin receptor agonists

Exclusion criteria

  • < 18 years
  • Purpura, Thrombocytopenic, Idiopathic, acute phase
  • pregnancy
  • others causes of thrombopenia

Trial design

36 participants in 2 patient groups

patients group
Description:
Adults patients with chronic immune thrombocytopenia
Treatment:
Biological: Biological tests
control group
Description:
Adults without immune thrombocytopenia
Treatment:
Biological: Biological tests

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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