Rehabilitation of Stroke Patients for Maximal Neurological Restoration (PROTEQT)

Norwegian University of Science and Technology

Status: Enrolling

Conditions: Stroke

Treatments: Behavioral: Kinematic movement analysis

Study type: Observational

Funder types: Other

Identifiers

NCT05086055

171264

Details and patient eligibility

About

Multimodal imaging of stroke patients. Patients included in the study will be investigated with multiparametric imaging tools including MRI and EEG imaging. Improvements in motor skills will be monitored clinically.

Full description

We aim to (i) quantify the size of the brain lesion and assess the surviving functional neural network connections; (ii) Analyze the type and degree of inflammation initiated by the stroke-induced brain lesion. We will stratify inflammation according to lesion volume, surviving functional neural network connections, age, NIHSS and Modified Rankin Scale (mRS) and analyze how inflammation markers change during rehabilitation; (iii) Train the surviving neural network to create new synaptic connections that can maximize restoration of motor functions; (iv) Apply and develop advanced mathematical and computational methods to model and predict how stroke rehabilitation can rewire the neural network connections to best facilitate restoration of lost motor function.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• subcortical strokes resulting in arm motor deficits.
• admitted to the stroke unit, St Olav´s Hospital during 2021-2023

Exclusion criteria

• Previous stroke
• neurodegenerative disease
• brain tumors
• previous neurotrauma or brain operation
• aphasia
• cognitive dysfunction and claustrophobia preventing MRI examinations.

Trial design

200 participants in 2 patient groups

Stroke patients

Description:

Stroke patients admitted to the stroke unit, St Olav´s hospital, Trondheim, Norway, without previous stroke, neurological disease or central nervous system (CNS) trauma, will be eligible for inclusion into the study. The planned cohort size is 135 patients.

Treatment:

Behavioral: Kinematic movement analysis

healthy volunteers

Description:

Age and gender matched controls without previous CNS disease or trauma are eligible for inclusion into the study. Estimated cohort size is 45 individuals. Volunteers will be recruited through announcement in local newspaper.

Treatment:

Behavioral: Kinematic movement analysis