Rehabilitation with Personalized Strategies According to Muscle Volume Before Knee Arthroplasty (REPERAGE)

Regional University Hospital Center (CHRU)

Status: Terminated

Conditions: Arthroplasty; Gonarthrosis

Treatments: Other: Global rehabilitation program; Other: Personalized rehabilitation program with electrostimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT04318197

29BRC.19.0154

Details and patient eligibility

About

Preoperative rehabilitation before total knee arthroplasty (TKA) has not been proven to be effective. Latest meta-analyzes do not find any improvement of motor performance during gait 6 months after surgery. However, most of the previous studies did not specifically target muscle atrophy to design rehabilitation protocol. Pre-operative muscle atrophy, although not systematic, is often observed. The preoperative muscles volumes of thigh muscles have been poorly identified and never used to adjust the pre operative rehabilitation strategy.

As part of the "FOLLOWKNEE" (RHU) project, which attempts to implement a personalized management of TKA and its follow-up, this study wants to explore the potential effect of adapted treatment to improve muscle force and muscle volume before TKA.

Enrollment: 15 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Terminal stage gonarthrosis with total knee arthroplasty (TKA) indication
• TKA indicated by the surgeon
• Body Mass Index < 35
• Acceptance to realize a preoperative rehabilitation in outpatient setting
• Adult between 18 and 80 years old
• Patient affiliated to social security
• Patient who signed an informed consent

Exclusion criteria

• Functionally uncomfortable osteoarticular illness (disabling pain, functional limitation of joint amplitudes or muscle strength) of controlateral leg.
• Unable or refusal to consent
• Contraindication to electrostimulation (skin lesion, nearby implanted metallic material, implanted cardiac or neurologic electrostimulator, intolerance to muscle electrical stimulation)
• Unstable medical situation preventing the continuous realization of a program of at least 4 weeks

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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15 participants in 3 patient groups

Global rehabilitation

Active Comparator group

Description:

2 hours of daily rehabilitation, 3 days per week during 4 weeks

Treatment:

Other: Global rehabilitation program

Personalized rehabilitation

Experimental group

Description:

2 hours of daily rehabilitation including at least 2 times 20 minutes of electrostimulation on atrophied muscles, 3 days per week during 4 weeks

Treatment:

Other: Personalized rehabilitation program with electrostimulation

Classic rehabilitation

No Intervention group

Description:

40 minutes of rehabilitation, once a week during 4 weeks.