Rehydration Efficiency During Ad-libitum Fluid Intake (LIV-D2O)

Arizona State University (ASU)

Status: Enrolling

Conditions: Dehydration

Treatments: Other: Liquid IV Hydration Multiplier; Other: Plain Water; Other: Liquid IV Sugar Free

Study type: Interventional

Funder types: Other

Identifiers

NCT06414291

FP00039672

Details and patient eligibility

About

It is well established that rehydration with a carbohydrate-electrolyte solution is more effective in comparison to plain water. This is primarily based on the sodium-glucose co transporter, based on which the world health organization has based its oral rehydration solution recommendations. Also, rehydration with a solution that includes sodium and glucose plasma osmolality should not drop as much as it happens during rehydration with water. As a result, we should have higher fluid intake due to higher thirst perception and lower urinary output due to higher levels of vasopressin.

The present study aims to examine the effectiveness of a electrolyte-glucose drink on rehydration following exercise-induced dehydration.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-60 years
• Training at least 2 times per week
• stable weight for the last 2 months (fluctuation less than 5 pounds)

Exclusion criteria

• Night shifting work
• Thyroid medication
• Bariatric surgery
• Cardiovascular disease
• Renal disease
• Hepatic disease
• Participating in another study at the same time
• Bodyweight over 110 pounds

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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20 participants in 3 patient groups, including a placebo group

Water

Placebo Comparator group

Description:

Rehydration with low mineral content bottle water

Treatment:

Other: Plain Water

Carbohydrate Electrolyte solution

Experimental group

Description:

Drink with 22 grams of carbohydrate, 1020 milligrams of sodium, and 760 milligrams of potassium per liter. Hydration multiplier liquid IV

Treatment:

Other: Liquid IV Hydration Multiplier

Low Sugar electrolyte solution

Experimental group

Description:

10 grams of carbohydrate, 1060 milligrams of sodium, and 760 milligrams of potassium per liter. Sugar free Liquid IV

Treatment:

Other: Liquid IV Sugar Free