Reinforcing Effects of Brief Exposures to Nitrous Oxide - 8

The University of Chicago

Status: Completed

Conditions: Opioid-Related Disorders; Substance-Related Disorders

Treatments: Drug: 60% N2O; Drug: 20% N2O; Drug: 80% N2O; Drug: 40% N2O

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00000256

R01-08391-8

R01DA008391 (U.S. NIH Grant/Contract)

NIDA-08391-8

Details and patient eligibility

About

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine reinforcing effects of brief exposures to nitrous oxide in healthy volunteers.

Enrollment: 11 patients

Sex: All

Ages: 22 to 34 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Please contact site for information.

Trial design

11 participants in 4 patient groups

Placebo + 20% N2O

Active Comparator group

Description:

0% N2O inhaled during psychomotor testing, 20% N2O inhaled during psycho motor testing, then subject's choice of the 2.

Treatment:

Drug: 20% N2O

Placebo + 40% N2O

Active Comparator group

Description:

0% N2O inhaled during psychomotor testing, 40% N2O inhaled during psycho motor testing, then subject's choice of the 2.

Treatment:

Drug: 40% N2O

Placebo + 60% N2O

Active Comparator group

Description:

0% N2O inhaled during psychomotor testing, 60% N2O inhaled during psycho motor testing, then subject's choice of the 2.

Treatment:

Drug: 60% N2O

Placebo + 80% N2O

Active Comparator group

Description:

0% N2O inhaled during psychomotor testing, 80% N2O inhaled during psycho motor testing, then subject's choice of the 2.

Treatment:

Drug: 80% N2O