Reinforcing Effects of Marijuana and Opioids

Shanna Babalonis, PhD

Status and phase: Enrolling; Phase 1

Conditions: Marijuana Use; Opioid Use

Treatments: Drug: Marijuana; Drug: Opioid

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT05485012

R01DA045700 (U.S. NIH Grant/Contract)

45017-20221

Details and patient eligibility

About

The primary goals of this study are to examine 1) marijuana modulation of oxycodone self-administration and 2) oxycodone modulation of marijuana self-administration, under controlled conditions and across a range of doses for each drug.

Enrollment: 12 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ages 18-50
• Experience with marijuana and opioids
• General good health
• Willing to live at the University of Kentucky Hospital (research unit) for approx. 6.5 weeks (meals are provided,

Exclusion criteria

• Significant medical complications/conditions

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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12 participants in 2 patient groups

Double-blind marijuana/placebo administration

Experimental group

Description:

Participants will receive double-blind administration of vaporized marijuana/placebo

Treatment:

Drug: Opioid

Drug: Marijuana

Double-blind opioid/placebo administration

Experimental group

Description:

Participants will receive double-blind administration of intranasal opioid agonist/placebo

Treatment:

Drug: Opioid

Drug: Marijuana