Relation Between Aldosterone and Cardiac Remodeling After Myocardial Infarction (REMI)

Central Hospital, Nancy, France

Status: Completed

Conditions: Myocardial Infarction

Treatments: Procedure: pulmonary echography; Procedure: renal echography; Biological: urine sample; Procedure: vascular check; Biological: blood sample; Procedure: MRI; Procedure: echocardiography

Study type: Interventional

Funder types: Other

Identifiers

NCT01109225

2009-A00537-50

Details and patient eligibility

About

This study aims to determine whether aldosterone blood levels are predictive of cardiac remodeling at 6 months following myocardial infarction with ST elevation (STEMI), independently of conventional predictive factors (size of myocardial infarction, age, hypertension, etc.) in revascularized patients during the acute phase of MI.

Full description

After myocardial infarction, the evolution toward cardiac failure is generally linked to a progressive worsening of cardiac dysfunction and remodeling. Cardiac remodeling is largely the consequence of myocardial injury due to myocardial infarction, although other parameters including age, arterial hypertension, etc. may also represent important predictors. Aldosterone blood levels measured within the first hours of admission for myocardial infarction is associated with increased rates of adverse outcomes. Aldosterone acts on wound healing and fibrosis processes in the myocardium as well as on systemic volemia.

Enrollment: 145 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Man or woman hospitalized for a first myocardial infarction with known shift of the segment ST revascularized in acute phase by primary angioplasty and dated less than 4 days
• Patient presenting a stable clinical state
• Patient presenting a regular sinusal cardiac rhythm
• Patient having an age ≥ 18 years

Exclusion criteria

• Counter-indication with examination MRI
• Severe claustrophobia
• Antecedent of over-sensitiveness to gadolinium salts
• Nonischaemic Cardiopathy
• Cardiac surgery planed in the 6 months
• Women into old to procreate without effective contraception

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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145 participants in 1 patient group

Myocardial infarction

Experimental group

Description:

All patients. Patients hospitalized for a first myocardial infarction with known shift of the segment ST revascularized in acute phase by primary angioplasty and dated less than 4 days. Intervention: * blood sample * MRI * echocardiography * urine sample * pulmonary echography * vascular check * renal echography

Treatment:

Procedure: echocardiography

Procedure: pulmonary echography

Procedure: renal echography

Biological: blood sample

Procedure: MRI

Procedure: vascular check

Biological: urine sample