Relationship Between Abnormalities of Desmin Cytoskeleton, Mitochondrial Activity and Expression of Ubiquitin in Aspect of Pathogenesis of Heart Failure and Prognosis (DESMIN)

Ministry of Scientific Research and Information Technology, Poland

Status: Unknown

Conditions: Dilated Cardiomyopathy

Treatments: Procedure: cardiobiopsy

Study type: Interventional

Funder types: Other

Identifiers

NCT00819442

N N402196135

Details and patient eligibility

About

The purpose of this study is evaluation of expression of desmin in cardiomyocytes of patients with idiopathic dilated cardiomyopathy. Analysis of relationship between desmin expression and activities of mitochondrium and expression of ubiquitin.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• idiopatic dilated cardiomyopathy, NYHA I, II, III, IV
• dilated left ventricle
• ejection fraction below 45%

Exclusion criteria

• diabetes mellitus
• kidney failure (GFR < 30, creatinine below 2,5 mg/dl

Trial design

60 participants in 3 patient groups, including a placebo group

1

Placebo Comparator group

Description:

patients without heart failure, with cardiobiopsy

Treatment:

Procedure: cardiobiopsy

2

Experimental group

Description:

patients with heart failure in NYHA class I, II

Treatment:

Procedure: cardiobiopsy

3

Experimental group

Description:

Patients with heart failure in NYHA class III, IV

Treatment:

Procedure: cardiobiopsy