Relationship Between Cardiopulmonary Exercise Testing and Ca-P in Chronic Kidney Disease (CKD)

Shahid Beheshti University of Medical Sciences

Status: Completed

Conditions: Ckd-Mbd

Treatments: Diagnostic Test: CPET

Study type: Observational

Funder types: Other

Identifiers

NCT04013139

SBMU2314

Details and patient eligibility

About

Reductions in exercise capacity associated with exercise intolerance augment cardiovascular disease risk and predict mortality in chronic kidney disease. This study utilized cardiopulmonary exercise testing to (a) investigate mechanisms of exercise intolerance; (b) unmask subclinical ca and p and vitamin D abnormalities that may precede cardiovascular disease in chronic kidney disease.

Full description

Cardiopulmonary exercise testing will carry out in Stage 3-5 chronic kidney disease patients ; estimated glomerular filtration rate <60 ml/min/1.73 m2) and biochemistry will be added (Ca P Via D PTH FGF23).

Enrollment: 200 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• CKD Patients with GFR <60 non-dialysis
• age<18

Exclusion criteria

• HTN
• not signing consent
• active coronary disease

Trial design

200 participants in 2 patient groups

CKD Stage 3

Description:

CKD patients with GFR between 30-60cc/min

Treatment:

Diagnostic Test: CPET

CKD Stage 4

Description:

CKD Patients with GFR 15-30 cc/min

Treatment:

Diagnostic Test: CPET