Relationship Between Cardiovascular Disease in Asthma and Eosinophil Subtypes and Biomarkers of Bronchial Remodeling.

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Status: Not yet enrolling

Conditions: Asthma; Cardiovascular Diseases

Treatments: Other: Asthma and cardiovascular disease

Study type: Observational

Funder types: Other

Identifiers

NCT05589779

IIBSP-ASM-2022-89

Details and patient eligibility

About

To know the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease.

Full description

Recent studies have shown that asthma could be a risk factor for cardiovascular disease, especially in the female and late-onset subgroups. The two entities share several risk factors, such as chronic inflammation and bronchial remodeling. Eosinophilia, characteristic of asthma, has also been described as a predictor of cardiovascular mortality.

The aim of this study is to determine the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease, as well as their relationship with eosinophil subtypes, biomarkers of chronic inflammation and bronchial remodeling.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Previous diagnosis of asthma
• Signed informed consent

Exclusion criteria

• Age under 18 years old
• Age over 99 years old
• Pneumological diseases other than asthma
• Active oncological diseases or with end of treatment <5 years
• Autoimmune or systemic inflammatory diseases

Trial design

40 participants in 2 patient groups

With cardiovascular disease

Description:

Asthma patients with cardiovascular disease

Treatment:

Other: Asthma and cardiovascular disease

Without cardiovascular disease

Description:

Asthma patients without cardiovascular disease

Treatment:

Other: Asthma and cardiovascular disease