Relationship Between Central Sensitization and Kinesiophobia in Knee Osteoarthritis

Selda Sarıkaya

Status

Completed

Conditions

Kinesiophobia

Knee Osteoarthritis

Central Sensitisation

Treatments

Diagnostic Test: Pressure Algometer

Study type

Observational

Funder types

Other

Identifiers

NCT06336278

19/03/2024

Details and patient eligibility

About

Objective: The knee joint is one of most common locations in OA. In recent years, it has been accepted that there are different pain phenotypes and patient subgroups in knee OA and that central sensitization (CS) mechanisms are at the forefront in some patients. It is also known that fear of movement, known as kinesiophobia, develops in patients with chronic pain. The aim of this study is to investigate CS and kinesiophobia in patients with knee OA, their relationships with each other, and their effects on pain intensity, functional status, pain catastrophizing and depression.

Materials and Methods: Forty-two patients with knee OA and 42 healthy subjects participated in our study. Demographic data, body mass index, habits, comorbidities, medications of participants and disease duration and radiographic grade of knee OA patients were recorded. VAS was used to assess the severity of pain and WOMAC was used to assess pain and functional status in patients with OA. Algometer (pressure pain threshold measurement) and Central Sensitization Inventory were used to evaluate central sensitization in all participants. Pressure pain threshold (PPT) was measured at 3 different points: knee joint, cruris and forearm. The presence of kinesiophobia was assessed with the Tampa Scale af Kinesiophobia (TSK). Pain Catastrophizing Scale (PCS) and Beck Depression Inventory (BDI) were used to assess chronic pain related symptoms.

Full description

Forty-two patients with knee OA and 42 healthy subjects participated in our study. Demographic data, body mass index, habits, comorbidities, medications of participants and disease duration and radiographic grade of knee OA patients were recorded. VAS was used to assess the severity of pain and WOMAC was used to assess pain and functional status in patients with OA. Algometer (pressure pain threshold measurement) and Central Sensitization Inventory were used to evaluate central sensitization in all participants. Pressure pain threshold (PPT) was measured at 3 different points: knee joint, cruris and forearm. The presence of kinesiophobia was assessed with the Tampa Scale af Kinesiophobia (TSK). Pain Catastrophizing Scale (PCS) and Beck Depression Inventory (BDI) were used to assess chronic pain related symptoms.

Enrollment

84 patients

Sex

All

Ages

45 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for knee osteoarthritis group:

Being a healthy volunteer between the ages of 45-75
Being diagnosed with knee osteoarthritis according to ACR diagnostic criteria
Knee pain for at least 6 months
Kellgren-Lawrence 1, 2 or 3 radiologic grade of knee OA
Body mass index below 35

Exclusion Criteria for knee osteoarthritis group:

Presence of chronic widespread painful diseases other than osteoarthritis (fibromyalgia syndrome etc.), rheumatologic disease, peripheral neuropathy
Presence of uncontrolled systemic disease
Cooperation limitation or cognitive impairment
Active arthritis in the knee joint to be evaluated
Presence of prosthesis in the knees
Pain in the forearm
Body mass index of 35 and above