Relationship Between Complex Regional Pain Syndrome and Magnesium Depletion Score

Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization

Status: Completed

Conditions: Complex Regional Pain Syndrome (CRPS)

Treatments: Other: scoring

Study type: Observational

Funder types: Other

Identifiers

NCT07093424

RSD1

Details and patient eligibility

About

Complex Regional Pain Syndrome (CRPS) is a condition triggered by trauma such as surgery or a fracture. It is characterised by pain and limited mobility that are disproportionate to the severity of the trauma and the clinical course. Magnesium is recognised for its anti-inflammatory and antioxidant properties. The magnesium depletion score (MDS) is a more reliable and comprehensive scoring tool than measuring serum and urine magnesium levels. This score takes into account the patient's use of diuretics and proton pump inhibitors, their alcohol consumption, and their glomerular filtration rate. Impaired magnesium distribution may be a risk factor for CRPS development due to increased nociceptor activity. This study aimed to investigate whether an increased MDS score is a risk factor for CRPS development in individuals with traumatic limb injury.

Enrollment: 117 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male and female patients aged 18-99 years with traumatic extremity injuries

Exclusion criteria

• History of previous stroke, spinal cord injury
• Presence of radiculopathy, radicular pain in the affected extremity
• Previous surgery for cervical discopathy/lumbar discopathy
• Presence of oncological, haematological diseases
• History of previous peripheral nerve injury or previous surgery

Trial design

117 participants in 1 patient group

traumatic extremity injury

Treatment:

Other: scoring