Relationship Between Computed Tomography Manifestation and Histopathological Classification of Thymic Epithelial Tumors

Military Hospital 103

Status: Completed

Conditions: Thymoma

Treatments: Other: CT and histopathological classification

Study type: Interventional

Funder types: Other

Identifiers

NCT03288662

LAnh

Details and patient eligibility

About

the World Health Organization (WHO) has proposed a classification of histopathological thymic tumor and it significance in prognosis. Chest computed tomography (CT) is the most common method to evaluate thymic epithelial tumors before operation. Therefore, the question is to predict the histopathological type of thymic epithelial tumors before surgery based on CT-scan images , to help determine treatment strategy and prognosis. In Vietnam, there are no published literature on this issue.

Full description

1. Introduction: the World Health Organization (WHO) has proposed a classification of histopathological thymic tumor and it significance in prognosis. Chest computed tomography (CT) is the most common method to evaluate thymic epithelial tumors before operation. Therefore, the question is to predict the histopathological type of thymic epithelial tumors before surgery based on CT-scan images , to help determine treatment strategy and prognosis. In Vietnam, there are no published literature on this issue.

2. Materials and methods:

   2.1. Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors

   2.2. Time and Place: in Departement of CTVS, Military Hospital 103, Vietnam from 10/2013 to 7/2017.

   2.3. methods:

   • study in chest CT scan:

     • Measure the maximun diameter of the tumor
     • The contour: smooth contour or irregular contour
     • The shape: round, oval and plaque base on the ratio between long axis and short axis of the tumor
     • Some other characteristics: Degree of enhancement, Level of drug absorbed, Calcification, Invasion the local organs and Capsular destruction.

   • Histopathological study: based on the 2004 WHO classification:

     • Thymoma: type A, AB, B1, B2, B3
     • Thymic carcinoma

   • Data processing: use software Epi Info 2000.

3. Expectation of results

   • Relationship between the size and histopathological type of thymic epithelial tumors.
   • Comparison of some characteristics of the tumor on preoperative chest CT scans and histopathological type of thymic epithelial tumors

Enrollment: 2 patients

Sex: All

Ages: 21 to 71 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All of patient have a chest CT scan pre-operation and a result of thymic epithelial tumors postoperative histopathology

Exclusion criteria

• Incomplete or loss the CT and postoperative histopathology

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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2 participants in 1 patient group

CT and histopathological classification

Experimental group

Description:

With each histopathological type of thymic epithelial tumors, we measure the maximun diameter in chest CT scan. Comparison of some characteristics of the tumor on preoperative chest CT scans and histopathological type of thymic epithelial tumors .

Treatment:

Other: CT and histopathological classification