Relationship Between Dopaminergic Asymmetric Degeneration and Attentional Resources in Parkinson's Disease. (RTsAsMIRT)

Ospedale Generale Di Zona Moriggia-Pelascini

Status

Completed

Conditions

Attention Disturbances

Parkinson Disease

Treatments

Other: MIRT

Study type

Interventional

Funder types

Other

Identifiers

NCT03476668

MIRT-RTs-Laterality

Details and patient eligibility

About

The researchers aimed to investigate the relationship between the asymmetric dopaminergic degeneration and the attentional resources in a group of patients with Parkinson's disease (PD).

Full description

To bypass the impaired habitual motor-behavioural control, Parkinson's disease (PD) patients may exploit the network of goal-directed mode of action. The frontostriatal connections underline this functioning, that is based on attention. Since the cognitive processes are related with dopamine, the asymmetrical degeneration of the dopaminergic system affects differently the right side affected (RPD) and the left side affected (LPD) PD patients.

The aim of the study was to investigate the relationship between the asymmetric dopaminergic degeneration and the attentional resources in a group of patients with PD.

Enrollment

100 patients

Sex

All

Ages

40 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Stage 2.5-3 according to the Hoehn and Yahr scale (H&Y);
Stable pharmacological treatment for the last 6 weeks before the enrolment and during the hospitalization;
Mini Mental State Examination (MMSE) ≥ 24;
No evidences of dysexecutive syndrome.

Exclusion criteria

Any focal brain lesion detected in brain imaging studies (CT or MRI) performed in the previous 12 months;
Drug-induced dyskinesias;
Disturbing resting and/or action tremor, corresponding to scores 2-4 in the specific items of UPDRS III;
Behavioral disturbances (evaluated with Neuropsychiatric Inventory);
Visual and auditory dysfunctions according to the general clinical evaluation and medical history;
Equivocal report about the side of disease onset or bilateral motor involvement.