Relationship Between Intestinal Flora Changes and Hyperuricemia Under Chronic Psychological Stress

Tongji University

Status: Completed

Conditions: Hyperuricemia

Treatments: Other: No interventions

Study type: Observational

Funder types: Other

Identifiers

NCT06984575

stress and hyperuricemia

Details and patient eligibility

About

To clarify the mechanism of stress on the incidence of hyperuricemia

Full description

To clarify the differences in intestinal microorganisms and metabolism between healthy people and hyperuricemia patients and across different level of stress

Enrollment: 67 patients

Sex: Male

Ages: 18 to 69 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Obtain the informed consent of the subjects before conducting any trial-related activities;
2. Males aged 18-69;
3. The hyperurcemia group must meet the diagnostic criteria of having blood uric acid >420umol/L measured twice on an empty stomach on different days under a normal purine diet;

Exclusion criteria

• 1)Use of any uric acid-lowering drugs, anti-gout drugs, steroids, proton pump inhibitors, or non-steroidal anti-inflammatory drugs within one month before enrollment; 2)Use of any antibiotics, probiotics, or other drugs including traditional Chinese medicine within one month before enrollment; 3)Abnormal liver function, ALT and AST are more than 2.5 times the upper limit of normal; 4)Other diseases that affect glucose and lipid metabolism: hyperthyroidism, hypothyroidism, hypercortisolism, etc.

5)Chronic kidney disease or severe renal impairment, according to eGFR grading <45mL/min/1.73m2; 6)Secondary hyperuricemia 7)Any gastrointestinal diseases

Trial design

67 participants in 4 patient groups

LSC

Description:

healthy people with low level of stress

Treatment:

Other: No interventions

HSC

Description:

healthy people with high level of stress

Treatment:

Other: No interventions

LSH

Description:

hyperuricemia patients with low level of stress

Treatment:

Other: No interventions

HSH

Description:

hyperuricemia patients with high level of stress

Treatment:

Other: No interventions