Relationship Between Left Ventricular Remodeling, Coronary Endothelial Function and Myocardial Fibrosis Using Positron Emission Tomography in Patients With ST-elevation Myocardial Infarction (REMOD-TEP)

Caen University Hospital

Status

Suspended

Conditions

ST Elevation Myocardial Infarction

Treatments

Other: (15)-O water positron emission tomography and Biomarkers

Study type

Interventional

Funder types

Other

Identifiers

NCT02789098

2015-A01650-49

Details and patient eligibility

About

Left ventricular remodeling is a common complication in patients with ST-elevation myocardial infarction (STEMI ) and may lead to heart failure. Hemodynamic, metabolic and inflammatory mechanisms are involved in this pathophysiological process. Recent data demonstrated that remote, noninfarct-related region of the myocardium is also implicated. There is no data about the assessment of coronary endothelial function or myocardial fibrosis in the remote zone in patients with STEMI . The correlation between these parameters and left ventricular remodeling is not known.

Enrollment

30 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

First ST Elevation Myocardial Infarction
Primary Percutaneous Coronary Intervention (TIMI 3)
Single vessel coronary artery disease
Age over 18 years
Informed Consent dated and signed
Written and spoken French
Beneficiary of social security insurance

Exclusion criteria

No Primary Percutaneous Coronary Intervention
TIMI 0-2 after Primary Percutaneous Coronary Intervention
Significant two or three-vessel coronary artery disease (> 70% stenosis in at least one of the other two coronary arteries)
Past history of myocardial infarction before STEMI
Mechanical complication (ischaemic mitral regurgitation, interventricular septal defect, cardiac tamponade) or clinical signs of heart failure
Pregnant and / or lactating
Age under 18 years or guardianship