Relationship Between LRG and Periodontal Disease

Aydin Adnan Menderes University

Status: Completed

Conditions: Periodontitis; Inflammation; Acute-Phase Response

Treatments: Other: Oral hygiene instructions; Other: Non-surgical periodontal treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT04383561

KAEK-92

Details and patient eligibility

About

This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)-6 and tumor necrosis factor (TNF)-α in patients with periodontitis before and after non-surgical periodontal treatment.

Full description

Twenty-five stage 3 periodontitis and twenty-five periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; periodontitis patients received non-surgical periodontal treatment, and GCF and serum samples were obtained at baseline and at 6 weeks after treatment. LRG, IL-6 and TNF-α were determined by ELISA.

Enrollment: 50 patients

Sex: All

Ages: 26 to 49 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. 25-50 years of age
2. having at least 20 natural teeth, excluding third molars
3. having no systemic disease
4. non-smokers
5. criteria for healthy control group: BOP < 10% and PD ≤ 3 mm without clinical attachment loss or radiographic sign of alveolar bone destruction
6. criteria for stage 3 periodontitis group: interdental CAL ≥ 5 mm at least 2 non-adjacent teeth, PD ≥ 6 mm and radiographic bone loss extending to the mid-third of the root or beyond.

Exclusion criteria

1. having any systemic diseases,
2. smoking
3. current pregnancy or lactation
4. a history of periodontal treatment in the past 6 months
5. using antibiotic, anti-inflammatory drugs or any other drugs within the past 6 months.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

50 participants in 2 patient groups, including a placebo group

stage 3 periodontitis

Active Comparator group

Description:

GCF and serum samples were collected before and after treatment from periodontitis patients.

Treatment:

Other: Oral hygiene instructions

Other: Non-surgical periodontal treatment

Periodontally healthy controls

Placebo Comparator group

Description:

GCF and serum samples were collected from periodontally healthy controls at baseline for once.

Treatment:

Other: Oral hygiene instructions